The long-standing pre-eminence of US technology and innovation worldwide may now face a challenge, as the changing face of the global marketplace takes its toll. As US trade and development has expanded overseas, partner nations have taken advantage of this access. Particularly in Asia, nations are making large strides in research and development (R&D) and other scientific technology. Budget troubles, declining numbers of graduates in technology-related fields, and foreign expertise “brain drain” may also hurt American R&D in the next decade. The United States still has a clear advantage, with its unparalleled resources and infrastructure, but it must innovate aggressively in order to remain one step ahead of global competitors.